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If pain becomes constant, burning, post-dental, viral-related, treatment-resistant, or does not match meaningful vascular compression on MRI, the problem may not be classical trigeminal neuralgia alone

Chronic, uninterrupted activation can lead to pathway desensitization, the biological equivalent of diminishing returns

and NVXCoV2373, Novavax), which were also based around ancestral sequences

By targeting specific areas around the head and neck, Botox injections prevent the activation of pain networks, thereby reducing both the frequency and severity of migraine attacks